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Use of synthetic IGF-1 analogs is prohibited at all times due to their performance-enhancing potential and influence on growth pathways. WADA Prohibited List, 2024 Legal Status in the United States and Globally Possession for personal research use is not criminalized in most jurisdictionsbut selling, distributing, or marketing IGF-1 peptides for human consumption can lead to regulatory penalties

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Consistently, over 70% of obese individuals with T2DM are known to have NAFLD, and NAFLD patients almost universally have T2DM and hepatic insulin resistance [82]

In the context of chronic weight management, dose increases may be warranted when weight loss is insufficient or plateaus before reaching clinically meaningful targets